Diverse Psychotomimetics Act Through a Common Signaling Pathway

  title={Diverse Psychotomimetics Act Through a Common Signaling Pathway},
  author={Per Svenningsson and Eleni T. Tzavara and Robert J. Carruthers and Ilan Rachleff and Sigrid Wattler and Michael Nehls and David McKinzie and Allen A. Fienberg and G. Nomikos and Paul Greengard},
  pages={1412 - 1415}
Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble schizophrenia symptoms in humans. Here we implicate a common signaling pathway in mediating these effects. In this pathway, dopamine- and an adenosine 3′,5′-monophosphate (cAMP)–regulated phospho-protein of 32 kilodaltons (DARPP-32) is phosphorylated or… 

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  • S. Snyder
  • Psychology, Medicine
    The American journal of psychiatry
  • 1973
The author discusses some implications of the roles dopamine and norepinephrine may play in mediating some schizophrenic symptoms.