Diverse Psychotomimetics Act Through a Common Signaling Pathway

@article{Svenningsson2003DiversePA,
  title={Diverse Psychotomimetics Act Through a Common Signaling Pathway},
  author={P. Svenningsson and E. Tzavara and R. Carruthers and Ilan Rachleff and S. Wattler and M. Nehls and D. Mckinzie and A. Fienberg and G. Nomikos and P. Greengard},
  journal={Science},
  year={2003},
  volume={302},
  pages={1412 - 1415}
}
Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble schizophrenia symptoms in humans. Here we implicate a common signaling pathway in mediating these effects. In this pathway, dopamine- and an adenosine 3′,5′-monophosphate (cAMP)–regulated phospho-protein of 32 kilodaltons (DARPP-32) is phosphorylated or… Expand
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