Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts.

@article{Ping1994DiverseGP,
  title={Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts.},
  author={Peipei Ping and H Kirk Hammond},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 2},
  pages={
          H2079-85
        }
}
Right atrial and left ventricular homogenates have similar protein composition and beta-adrenergic receptor (beta-AR) numbers, but the right atrium has > 58% less adenylyl cyclase activity than the left ventricle. Associated with distinctive patterns of adenylyl cyclase activities are differences in G protein regulation between the two chambers. Compared with the left ventricle, the right atrium has 74% less Gs alpha mRNA (P < 0.0001) and 83% less G alpha i-2 mRNA (P < 0.002). When hearts are… CONTINUE READING
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