Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library.

@article{Farrar1997DiverseFS,
  title={Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library.},
  author={J. K. Farrar and S Portolano and Nick Willcox and Angela Vincent and Leslie Jacobson and John Newsom-Davis and Basil Rapoport and S M Mclachlan},
  journal={International immunology},
  year={1997},
  volume={9 9},
  pages={1311-8}
}
The muscle weakness in myasthenia gravis (MG) is caused by heterogeneous high-affinity IgG autoantibodies to the nicotinic acetylcholine receptor (AChR), a complex ion channel glycoprotein. These antibodies are clearly responsible for reducing AChR numbers at the neuromuscular junction in myasthenia; however, the origins, diversity, specificity and pathogenicity of individual antibodies have not yet been established. We have cloned and characterized four different AChR-specific Fab from an MG… CONTINUE READING
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