Diverse Domains of (Cytosine-5)-DNA Methyltransferases: Structural and Functional Characterization

@inproceedings{Ryazanova2012DiverseDO,
  title={Diverse Domains of (Cytosine-5)-DNA Methyltransferases: Structural and Functional Characterization},
  author={A. Yu. Ryazanova and Liudmila A Abrosimova and Tatiana S. Oretskaya and Elena A. Kubareva},
  year={2012}
}
(Cytosine-5)-DNA methyltransferases (C5-DNA MTases) are enzymes which catalyze meth‐ yl group transfer from S-adenosyl-L-methionine (AdoMet) to C5 atom of cytosine residue in DNA. As a result, AdoMet is converted into S-adenosyl-L-homocysteine (AdoHcy). The rec‐ ognition sites of C5-DNA MTases are usually short palindromic sequences (2–6 bp) in dou‐ ble-stranded DNA. One or both DNA strands can be methylated. The introduced methyl group is localized in the major groove of the DNA double helix… CONTINUE READING

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