Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells

@article{Abbot2005DivergingRO,
  title={Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells},
  author={Emily L. Abbot and James G. Mccormack and Christine Reynet and David G. Hassall and Kevin W. Buchan and Stephen J. Yeaman},
  journal={The FEBS Journal},
  year={2005},
  volume={272}
}
The pyruvate dehydrogenase complex occupies a central and strategic position in muscle intermediary metabolism and is primarily regulated by phosphorylation/dephosphorylation. The identification of multiple isoforms of pyruvate dehydrogenase kinase (PDK1–4) and pyruvate dehydrogenase phosphatase (PDP1–2) has raised intriguing new possibilities for chronic pyruvate dehydrogenase complex control. Experiments to date suggest that PDK4 is the major isoenzyme responsible for changes in pyruvate… 

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