Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy.

  title={Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy.},
  author={Bruce J. Aronow and Tsuyoshi Toyokawa and A. A. Canning and Kobra Haghighi and Ulrike Delling and Evangelia G Kranias and Jeffery D Molkentin and Gerald W. Dorn},
  journal={Physiological genomics},
  volume={6 1},
To define molecular mechanisms of cardiac hypertrophy, genes whose expression was perturbed by any of four different transgenic mouse hypertrophy models [protein kinase C-epsilon activation peptide (PsiepsilonRACK), calsequestrin (CSQ), calcineurin (CN), and Galpha(q)] were compared by DNA microarray analyses using the approximately 8,800 genes present on the Incyte mouse GEM1. The total numbers of regulated genes (tens to hundreds) correlated with phenotypic severity of the model (Galpha(q… CONTINUE READING
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Cardiotrophic effects of e protein kinase C: analysis by in vivo modulation of ePKC translocation

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