Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

  title={Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.},
  author={Alla A. Sigova and Alan C. Mullen and Benoit Molinie and Sumeet Gupta and David A. Orlando and Matthew G. Guenther and Albert E. Almada and Charles Lin and Phillip A. Sharp and Cosmas C. Giallourakis and Richard A. Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 8},
Many long noncoding RNA (lncRNA) species have been identified in mammalian cells, but the genomic origin and regulation of these molecules in individual cell types is poorly understood. We have generated catalogs of lncRNA species expressed in human and murine embryonic stem cells and mapped their genomic origin. A surprisingly large fraction of these transcripts (>60%) originate from divergent transcription at promoters of active protein-coding genes. The divergently transcribed lncRNA/mRNA… CONTINUE READING
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