Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.

@article{Ding2014DivergentTS,
  title={Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.},
  author={R. Ding and Jian-guo Fu and Guangqiang Xu and B. Sun and Guo-qiang Lin},
  journal={The Journal of organic chemistry},
  year={2014},
  volume={79 1},
  pages={
          240-50
        }
}
  • R. Ding, Jian-guo Fu, +2 authors Guo-qiang Lin
  • Published 2014
  • Medicine, Chemistry
  • The Journal of organic chemistry
  • Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B, and the first total synthesis of huperzine U have been achieved efficiently in overall yields of 17%, 10%, and 9%, respectively, each spanning 10-13 steps from (R)-pulegone. The featured steps include palladium-catalyzed Buchwald-Hartwig… CONTINUE READING
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