Divergent total syntheses of lyconadins A and C.


Divergent and concise total syntheses of two lycopodium alkaloids, lyconadins A and C have been developed. The synthesis of lyconadin A, having potent neurotrophic activity, features an efficient one-pot ketal removal and formal aza-[4+2] cyclization to form the cagelike core structure. A tandem ketal removal/Mannich reaction was developed to build the tricyclic structure of lyconadin C. Both lyconadins A and C were synthesized from a pivotal intermediate.

DOI: 10.1002/anie.201400416

Cite this paper

@article{Yang2014DivergentTS, title={Divergent total syntheses of lyconadins A and C.}, author={Yang Yang and Christopher W Haskins and Wandi Zhang and Pui Leng Low and Mingji Dai}, journal={Angewandte Chemie}, year={2014}, volume={53 15}, pages={3922-5} }