Divergent stalling sequences sense and control cellular physiology.

  title={Divergent stalling sequences sense and control cellular physiology.},
  author={Koreaki Ito and Shinobu Chiba and Kit Pogliano},
  journal={Biochemical and biophysical research communications},
  volume={393 1},
Recent studies have identified several amino acid sequences that interact with the ribosomal interior components and arrest their own elongation. Whereas stalling of the inducible class depends on specific low-molecular weight compounds, that of the intrinsic class is released when the nascent chain is transported across or inserted into the membrane. The stalled ribosome alters messenger RNA secondary structure and thereby contributes to regulation of the cis-located target gene expression at… CONTINUE READING
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