Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field

@inproceedings{Eizaguirre2012DivergentSO,
  title={Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field},
  author={Christophe Eizaguirre and Tobias L Lenz and Martin Kalbe and Manfred Milinski},
  booktitle={Ecology letters},
  year={2012}
}
Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Immunogenetic novelty confers a selective advantage in host-pathogen coevolution.

Proceedings of the National Academy of Sciences of the United States of America • 2018
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Dispersion patterns of parasites in 0 + year three-spined sticklebacks: a cross population comparison

M. Kalbe, K. M. Wegner, T.B.H. Reusch
J. Fish Biol., • 2002
View 6 Excerpts
Highly Influenced

Rapid and adaptive

C. Eizaguirre, T. L. Lenz, M. Kalbe, M. Milinski
2012
View 5 Excerpts
Highly Influenced

How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings.

Proceedings. Biological sciences • 2010
View 4 Excerpts
Highly Influenced

Relative importance of MHC

G. Rauch, M. Kalbe, T.B.H. Reusch
2006
View 6 Excerpts
Highly Influenced

The Coevolutionary Process

J. N. Thompson
1994
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…