Divergent roles of RAS1 and RAS2 in yeast longevity.

@article{Sun1994DivergentRO,
  title={Divergent roles of RAS1 and RAS2 in yeast longevity.},
  author={Jiying Sun and Sharad P. Kale and Andrew Childress and C Pinswasdi and S. Michal Jazwinski},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 28},
  pages={18638-45}
}
Individual cells of the yeast Saccharomyces cerevisiae have a limited replicative life-span. The role of the genes RAS1 and RAS2 in yeast longevity was examined. Over-expression of RAS2 led to a 30% increase in the life-span on average and postponed the senescence-related increase in generation time seen during yeast aging. No life-span extension was obtained by overexpression of RAS1. However, deletion of RAS1 prolonged the life-span. These results suggest that RAS1 and RAS2 play reciprocal… CONTINUE READING

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