Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

@article{LagierTourenne2012DivergentRO,
  title={Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs},
  author={Clotilde Lagier-Tourenne and Magdalini Polymenidou and Kasey R. Hutt and Anthony Q. Vu and Michael W Baughn and Stephanie C. Huelga and Kevin M. Clutario and Shuo-Chien Ling and Tiffany Y. Liang and Curt Mazur and Edward V. Wancewicz and Aneeza S. Kim and Andy Watt and Sue Freier and Geoffrey G. Hicks and John Paul Donohue and Lily Shiue and C. F. Bennett and John Ravits and Don W Cleveland and Gene W. Yeo},
  journal={Nature Neuroscience},
  year={2012},
  volume={15},
  pages={1488-1497}
}
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS binds to RNAs from >5,500 genes in mouse and human brain, primarily through a GUGGU-binding motif. We identified a sawtooth-like binding pattern, consistent with co… CONTINUE READING