Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice.

  title={Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice.},
  author={G Ranganayakulu and David A Elliott and Richard P. Harvey and Eric N Olson},
  volume={125 16},
Recent evidence suggests that cardiogenesis in organisms as diverse as insects and vertebrates is controlled by an ancient and evolutionarily conserved transcriptional pathway. In Drosophila, the NK-2 class homeobox gene tinman (tin) is expressed in cardiac and visceral mesodermal progenitors and is essential for their specification. In vertebrates, the tin homologue Nkx2-5/Csx and related genes are expressed in early cardiac and visceral mesodermal progenitors. To test for an early cardiogenic… CONTINUE READING

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