Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.

@article{Healy2005DivergentRO,
  title={Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.},
  author={Zachary R. Healy and Norman H. Lee and Xiangqun Gao and Mary B Goldring and P. G. Talalay and Thomas Wells Kensler and Konstantinos Konstantopoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 39},
  pages={
          14010-5
        }
}
Fluid shear exerts anti-inflammatory and anti-apoptotic effects on endothelial cells by inducing the coordinated expression of phase 2 detoxifying and antioxidant genes. In contrast, high shear is pro-apoptotic in chondrocytes and promotes matrix degradation and cartilage destruction. We have analyzed the mechanisms regulating shear-mediated chondrocyte apoptosis by cDNA microarray technology and bioinformatics. We demonstrate that shear-induced cyclooxygenase (COX)-2 suppresses… CONTINUE READING

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