Divergent response profile in activated cord blood T cells from first-born child implies birth-order-associated in utero immune programming.

Abstract

BACKGROUND First-born children are at higher risk of developing a range of immune-mediated diseases. The underlying mechanism of 'birth-order effects' on disease risk is largely unknown, but in utero programming of the child's immune system may play a role. OBJECTIVE We studied the association between birth order and the functional response of stimulated… (More)
DOI: 10.1111/all.12799

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