Divergent regulation of the murine CC chemokine C10 by Th(1) and Th(2) cytokines.

@article{Orlofsky2000DivergentRO,
  title={Divergent regulation of the murine CC chemokine C10 by Th(1) and Th(2) cytokines.},
  author={Amos Z. Orlofsky and Yao-Ming Wu and Michael B. Prystowsky},
  journal={Cytokine},
  year={2000},
  volume={12 3},
  pages={220-8}
}
Chemokines are typically found as products of acute stimulation of host defence cells. In contrast, the mouse CC chemokine C10 was previously shown to be a delayed, stably induced product of macrophages treated with interleukin 3 (IL-3), IL-4 or GM-CSF. We investigated the possibility that C10 is differentially regulated by cytokines associated with Th(1)and Th(2)cells. Northern blot analysis of bone marrow-derived macrophages showed that, in addition to IL-4, the Th(2)-specific cytokines IL-10… CONTINUE READING