Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

@article{Taniguchi2006DivergentRO,
  title={Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.},
  author={Cullen M. Taniguchi and Tatsuya Kondo and Mini P. Sajan and Ji Luo and Roderick Bronson and Tomoichiro Asano and Robert Farese and Lewis C. Cantley and C. Ronald Kahn},
  journal={Cell metabolism},
  year={2006},
  volume={3 5},
  pages={
          343-53
        }
}
Although the class I(A) phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin, its mechanism of action is not well understood. To identify the role of the PI3K pathway in insulin regulation of hepatic function, we ablated the expression of both major regulatory subunits of PI3K by crossing mice lacking Pik3r1 in liver with Pik3r2 null mice, creating liver-specific double knockout mice (L-p85DKO). L-p85DKO mice failed to activate PI3K or generate PIP(3) upon… CONTINUE READING

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