Divergent pharmacological responses to two calmodulin inhibitors, chlorpromazine and W-7, in rat pancreatic acinar cells.

@article{Heisler1984DivergentPR,
  title={Divergent pharmacological responses to two calmodulin inhibitors, chlorpromazine and W-7, in rat pancreatic acinar cells.},
  author={S I Heisler and Annie Fortin},
  journal={Canadian journal of physiology and pharmacology},
  year={1984},
  volume={62 3},
  pages={309-13}
}
The possible role of calmodulin in exocytotic secretion is supported by the presence of this calcium-binding protein in secretory cells, and by the antisecretory effects in intact secretory cells of substances which can antagonize calmodulin-stimulated enzymes in broken cell preparations. In this study, two in vitro calmodulin antagonists, W-7 and… CONTINUE READING