Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.

@article{Tackenberg2009DivergentPM,
  title={Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.},
  author={Christian Tackenberg and Roland Brandt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 46},
  pages={14439-50}
}
Alzheimer's disease is characterized by synaptic alterations and neurodegeneration. Histopathological hallmarks represent amyloid plaques composed of amyloid-beta (Abeta) and neurofibrillary tangles containing hyperphosphorylated tau. To determine whether synaptic changes and neurodegeneration share common pathways, we established an ex vivo model using organotypic hippocampal slice cultures from amyloid precursor protein transgenic mice combined with virus-mediated expression of EGFP-tagged… CONTINUE READING

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