Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins

@inproceedings{Wordeman2016DivergentMA,
  title={Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins},
  author={Linda Wordeman and Justin Decarreau and Juan Jesus Vicente and Michael J. Wagenbach},
  booktitle={Molecular biology of the cell},
  year={2016}
}
Depletion of microtubule (MT) regulators can initiate stable alterations in MT assembly rates that affect chromosome instability and mitotic spindle function, but the manner by which cellular MT assembly rates can stably increase or decrease is not understood. To investigate this phenomenon, we measured the response of microtubule assembly to both rapid and long-term loss of MT regulators MCAK/Kif2C and Kif18A. Depletion of MCAK/Kif2C by siRNA stably decreases MT assembly rates in mitotic… CONTINUE READING
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