Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.

@article{Roos2005DivergentMO,
  title={Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.},
  author={Baukje de Roos and Garry J. Rucklidge and Martin Reid and Karen Ross and Gary C. Duncan and Maria Angeles Rodr{\'i}guez Navarro and Jos{\'e} Miguel Arbones-Mainar and Mario A Guzm{\'a}n-Garc{\'i}a and Jes{\'u}s Osada and J. Browne and Christine E. Loscher and Helen M. Roche},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 12},
  pages={1746-8}
}
Conjugated linoleic acids (CLA) affect atherogenesis, but mechanisms are not well understood. We explored how two isomers of CLA, cis9, trans11-CLA and trans10, cis12-CLA, affected lipid and glucose metabolism, as well as hepatic protein expression, in apolipoprotein E knockout mice. After 12 wk of intervention, plasma triglyceride, NEFA, and glucose concentrations were significantly higher in the trans10, cis12-CLA group, whereas plasma triglyceride, NEFA, glucose, and insulin concentrations… CONTINUE READING
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