Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.

Abstract

Histone deacetylases (HDACs) play diverse roles in many diseases including cancer, sarcopenia, and Alzheimer's. Different isoforms of HDACs appear to play disparate roles in the cell and are associated with specific diseases; as such, a substantial effort has been made to develop isoform-selective HDAC inhibitors. Our group focused on developing HDAC1/HDAC2… (More)
DOI: 10.1021/bi400936h

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Cite this paper

@article{Kral2014DivergentKD, title={Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.}, author={Astrid M. Kral and Nicole D S Ozerova and Joshua Close and Joon Chul Jung and Melissa Chenard and Judith C. Fleming and Brian B. Haines and Paul Harrington and John Maclean and Thomas A. Miller and Paul J Secrist and Hongmei Wang and Richard W. Heidebrecht}, journal={Biochemistry}, year={2014}, volume={53 4}, pages={725-34} }