Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction.

@article{Bielen2007DivergentFO,
  title={Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction.},
  author={Holger Bielen and Sabine Oberleitner and Sylvain Marcellini and Lydia Gee and Patrick Lemaire and Hans Robert Bode and Ralph A. W. Rupp and Ulrich Technau},
  journal={Development},
  year={2007},
  volume={134 23},
  pages={4187-97}
}
Homologues of the T-box gene Brachyury play important roles in mesoderm differentiation and other aspects of early development in all bilaterians. In the diploblast Hydra, the Brachyury homologue HyBra1 acts early in the formation of the hypostome, the location of the organiser in adult Hydra. We now report the isolation and characterisation of a second Brachyury gene, HyBra2. Sequence analysis suggests that HyBra1 and HyBra2 are paralogues, resulting from an ancient lineage-specific gene… CONTINUE READING

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