Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

  title={Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury},
  author={Simone Monika Blattner and Jeffrey B. Hodgin and Masashi Nishio and Stephanie Wylie and Jharna Saha and Abdul Soofi and Courtenay Vining and Ann Randolph and Nadja Herbach and Ruediger Wanke and Kevin B. Atkins and Hee Gyung Kang and Anna Henger and Cord Brakebusch and Lawrence B. Holzman and Matthias Kretzler},
  booktitle={Kidney international},
Podocytes are highly specialized epithelial cells with complex actin cytoskeletal architecture crucial for maintenance of the glomerular filtration barrier. The mammalian Rho GTPases Rac1 and Cdc42 are molecular switches that control many cellular processes, but are best known for their roles in the regulation of actin cytoskeleton dynamics. Here, we employed podocyte-specific Cre-lox technology and found that mice with deletion of Rac1 display normal podocyte morphology without glomerular… CONTINUE READING
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