Divergent effects of l-arginine-NO pathway modulators on diazepam and flunitrazepam responses in NOR task performance

@article{Orzelska2015DivergentEO,
  title={Divergent effects of l-arginine-NO pathway modulators on diazepam and flunitrazepam responses in NOR task performance},
  author={Jolanta Orzelska and Sylwia Talarek and Joanna Listos and Sylwia Fidecka},
  journal={Behavioural Brain Research},
  year={2015},
  volume={284},
  pages={179-186}
}
The goal of the study was an evaluation of the degree, in which nitric oxide (NO) is involved in the benzodiazepines (BZs)-induced recognition memory impairment in rats. The novel object recognition (NOR) test was used to examine recognition memory. The current research focused on the object memory impairing effects of diazepam (DZ; 0.5 and 1mg/kg, sc) and flunitrazepam (FNZ; 0.1 and 0.2mg/kg; sc) in 1-hour delay periods in rats. It was found that acute ip injection of L-arginine (L-arg; 250… CONTINUE READING
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