Divergent effects of glucocorticoids on cortical and trabecular compartment BMD in childhood nephrotic syndrome.

@article{Wetzsteon2009DivergentEO,
  title={Divergent effects of glucocorticoids on cortical and trabecular compartment BMD in childhood nephrotic syndrome.},
  author={Rachel J. Wetzsteon and Justine Shults and Babette S Zemel and Pooja U Gupta and Jon M. Burnham and Rita M. Herskovitz and Krista M Howard and Mary B. Leonard},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 3},
  pages={503-13}
}
Glucocorticoid (GC) effects on skeletal development have not been established. The objective of this pQCT study was to assess volumetric BMD (vBMD) and cortical dimensions in childhood steroid-sensitive nephrotic syndrome (SSNS), a disorder with minimal independent deleterious skeletal effects. Tibia pQCT was used to assess trabecular and cortical vBMD, cortical dimensions, and muscle area in 55 SSNS (age, 5-19 yr) and >650 control participants. Race-, sex-, and age-, or tibia length-specific Z… CONTINUE READING