Divergent effects of ephedrine and phenylephrine on cardiovascular hemodynamics of near-term fetal sheep exposed to hypoxemia and maternal hypotension.

@article{Erkinaro2007DivergentEO,
  title={Divergent effects of ephedrine and phenylephrine on cardiovascular hemodynamics of near-term fetal sheep exposed to hypoxemia and maternal hypotension.},
  author={Tiina Erkinaro and Kaarin M{\"a}kikallio and Ganesh Acharya and Mervi P{\"a}kkil{\"a} and Tomi Kavasmaa and James Huhta and Seppo Alahuhta and Juha R{\"a}s{\"a}nen},
  journal={Acta anaesthesiologica Scandinavica},
  year={2007},
  volume={51 7},
  pages={922-8}
}
BACKGROUND We hypothesized that the administration of ephedrine and phenylephrine for maternal hypotension modifies cardiovascular hemodynamics in near-term sheep fetuses. METHODS At 115-136 days of gestation, chronically instrumented, anesthetized ewes with either normal placental function or increased placental vascular resistance after placental embolization were randomized to receive boluses of ephedrine (n = 12) or phenylephrine (n = 12) for epidural-induced hypotension after a short… CONTINUE READING
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