Divergent effects of dihydropyridine and phenylalkylamine calcium channel antagonist classes on autonomic function in human hypertension.

@article{Kailasam1995DivergentEO,
  title={Divergent effects of dihydropyridine and phenylalkylamine calcium channel antagonist classes on autonomic function in human hypertension.},
  author={Mala T. Kailasam and Robert J. Parmer and Justine H. Cervenka and Ronald Y Wu and Michael G. Ziegler and Brian P Kennedy and I A Adegbile and Daniel T. O'Connor},
  journal={Hypertension},
  year={1995},
  volume={26 1},
  pages={143-9}
}
Calcium channel antagonists differ by class in reported frequency of side effects that suggest reflex sympathoadrenal activation. Do such differences result from differential effects on autonomic and baroreflex function? The present study compared acute and chronic effects of two classes of calcium channel antagonists, the dihydropyridine type (felodipine) and the phenylalkylamine type (verapamil), on efferent sympathetic outflow and baroreflex slope in 15 essential hypertensive subjects. Blood… CONTINUE READING

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