Divergent effects of astroglial and microglial secretions on neuron growth and survival

@article{Vaca1992DivergentEO,
  title={Divergent effects of astroglial and microglial secretions on neuron growth and survival},
  author={Kenneth W. Vaca and Emily R. Wendt},
  journal={Experimental Neurology},
  year={1992},
  volume={118},
  pages={62-72}
}
Brain glia have a secretory capacity which can modulate neuronal function. Astrocytes release proteins which enhance neuronal survival and induce neuronal growth and differentiation. These effects can be blocked by antagonists of voltage-dependent calcium channels and may be partly mimicked by Bay K 8644, a calcium channel agonist. Two of these neurotrophic proteins appear, on the basis of their physical properties and effects on ciliary ganglion neurons, to be ciliary neurotrophic factor and… CONTINUE READING
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