Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats

@inproceedings{Moreno2013DivergentEO,
  title={Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats},
  author={Margarita Moreno and Daina Economidou and Adam C. Mar and C. L{\'o}pez-Granero and Daniele Caprioli and Delphine Theobald and Anushka B. P. Fernando and Amy Hauck Newman and T. W. Robbins and Jeffrey W. Dalley},
  booktitle={Psychopharmacology},
  year={2013}
}
Previously we demonstrated reduced D2/3 receptor availability in the ventral striatum of hyper-impulsive rats on the five-choice serial reaction time task (5-CSRTT). However, the anatomical locus of D2/3 receptor dysfunction in high impulsive (HI) rats is unknown. In the present study, we investigated whether D2/3 receptor dysfunction in HI rats is localised to the core or shell sub-regions of the nucleus accumbens (NAcb). Rats were selected for low (low impulsive, LI) and high impulsivity on… CONTINUE READING
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