Divergent differentiation in pleomorphic xanthoastrocytoma. Evidence for a neuronal element and possible relationship to ganglion cell tumors.

@article{Powell1996DivergentDI,
  title={Divergent differentiation in pleomorphic xanthoastrocytoma. Evidence for a neuronal element and possible relationship to ganglion cell tumors.},
  author={Suzanne Zein-Eldin Powell and Anthony T. Yachnis and Lucy Balian Rorke and Amyn M Rojiani and Thomas A. Eskin},
  journal={The American journal of surgical pathology},
  year={1996},
  volume={20 1},
  pages={80-5}
}
We report the detection of cytoplasmic immunoreactivity for neuronal/neuroendocrine antigens in a subpopulation of tumor cells within seven pleomorphic xanthoastrocytomas (PXAs). The expression of glial and neuronal polypeptides was examined in routinely prepared surgical resections by immunohistochemistry using well-characterized antibodies that recognize glial fibrillary acidic protein (GFAP), synaptophysin (SYN), and neurofilament triplet polypeptides (NFPs) in microwave-enhanced single- and… CONTINUE READING

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