Divergent coronary flow responses to uridine adenosine tetraphosphate in atherosclerotic ApoE knockout mice

@inproceedings{Teng2017DivergentCF,
  title={Divergent coronary flow responses to uridine adenosine tetraphosphate in atherosclerotic ApoE knockout mice},
  author={Bunyen Teng and Hicham Labazi and Changyan Sun and Yan Yang and Xiaorong Zeng and S Jamal Mustafa and Zhichao Zhou},
  booktitle={Purinergic Signalling},
  year={2017}
}
Uridine adenosine tetraphosphate (Up4A) exerts potent relaxation in porcine coronary arteries that is reduced following myocardial infarction, suggesting a crucial role for Up4A in the regulation of coronary flow (CF) in cardiovascular disorders. We evaluated the vasoactive effects of Up4A on CF in atherosclerosis using ApoE knockout (KO) mice ex vivo and in vivo. Functional studies were conducted in isolated mouse hearts using the Langendorff technique. Immunofluorescence was performed to… CONTINUE READING
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