Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

@inproceedings{Li2016DivergentBY,
  title={Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin},
  author={Zhong-rui Li and Jie Li and Jin-Ping Gu and Jennifer Yuet Ha Lai and Brendan M Duggan and Wei-Peng Zhang and Z Li and Yong-Xin Li and Rong-Biao Tong and Ying Xu and Dong-hai Lin and Bradley S Moore and Pei-Yuan Qian},
  booktitle={Nature chemical biology},
  year={2016}
}
Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial… CONTINUE READING
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Supplementary Fig UPLC-MS analysis of the feeding experiment. L-[ 15 N 2 ]asparagine (b)

Supplementary Fig UPLC-MS analysis of the feeding experiment. L-[ 15 N 2 ]asparagine (b)

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