Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle.

@article{Khachatoorian2012DivergentAE,
  title={Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle.},
  author={Ronik Khachatoorian and Vaithilingaraja Arumugaswami and Santanu Raychaudhuri and George K Yeh and Eden M Maloney and Julie T-W. Wang and Asim K. Dasgupta and Samuel French},
  journal={Virology},
  year={2012},
  volume={433 2},
  pages={346-55}
}
We have previously demonstrated that quercetin, a bioflavonoid, blocks hepatitis C virus (HCV) proliferation by inhibiting NS5A-driven internal ribosomal entry site (IRES)-mediated translation of the viral genome. Here, we investigate the mechanisms of antiviral activity of quercetin and six additional bioflavonoids. We demonstrate that catechin, naringenin, and quercetin possess significant antiviral activity, with no associated cytotoxicity. Infectious virion secretion was not significantly… CONTINUE READING
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