Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins.

@article{Kohsaka1993DivergentTC,
  title={Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins.},
  author={H Kohsaka and Pojen P. Chen and Akihiro Taniguchi and William E. R. Ollier and Dennis Anthony Carson},
  journal={Arthritis and rheumatism},
  year={1993},
  volume={36 2},
  pages={213-21}
}
OBJECTIVE To determine if the expressed T cell receptor (TCR) gamma repertoire is altered in rheumatoid arthritis (RA). METHODS Peripheral blood lymphocytes were collected from monozygotic twins who were either concordant or discordant for RA, or from a normal twin pair. TCR gamma-specific complementary DNA libraries were constructed using the anchored polymerase chain reaction. Gene usage was analyzed by plaque hybridization and sequencing. RESULTS The expressed TCR V gamma repertoires… CONTINUE READING

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