Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

Abstract

Like neutrophilic leukocytes, differentiated HL-60 cells respond to chemoattractant by adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading edge and contractile actin-myosin complexes at the back and sides. Experiments with pharmacological inhibitors, toxins, and mutant proteins show that this polarity depends on divergent… (More)
DOI: 10.1016/S0092-8674(03)00555-5

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Cite this paper

@article{Xu2003DivergentSA, title={Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils}, author={Jingsong Xu and Fei Wang and Alexandra Van Keymeulen and Paul Herzmark and Aaron F Straight and Kathleen M. Kelly and Yoh Takuwa and Naotoshi Sugimoto and Timothy J Mitchison and Henry Bourne}, journal={Cell}, year={2003}, volume={114}, pages={201-214} }