Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

  title={Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.},
  author={Christopher A Fuhrman and Wen-I Yeh and Howard R Seay and Priya Saikumar Lakshmi and Gaurav Chopra and Lin Zhang and Daniel J. Perry and Stephanie A. McClymont and Mahesh Kumar Yadav and M. Cecilia Lopez and Henry V Baker and Ying Zhang and Yizheng Li and Maryann Z Whitley and David von Schack and Mark A Atkinson and Jeffrey A Bluestone and Todd M Brusko},
  journal={Journal of immunology},
  volume={195 1},
Regulatory T cells (Tregs) play a central role in counteracting inflammation and autoimmunity. A more complete understanding of cellular heterogeneity and the potential for lineage plasticity in human Treg subsets may identify markers of disease pathogenesis and facilitate the development of optimized cellular therapeutics. To better elucidate human Treg subsets, we conducted direct transcriptional profiling of CD4(+)FOXP3(+)Helios(+) thymic-derived Tregs and CD4(+)FOXP3(+)Helios(-) T cells… CONTINUE READING
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