Divergent Immune Responses in Male and Female Mice after Trauma-Hemorrhage: Dimorphic Alterations in T Lymphocyte Steroidogenic Enzyme Activities.

@article{Samy2001DivergentIR,
  title={Divergent Immune Responses in Male and Female Mice after Trauma-Hemorrhage: Dimorphic Alterations in T Lymphocyte Steroidogenic Enzyme Activities.},
  author={T. S. Anantha Samy and Markus W Kno Ferl and Rui Zheng and Martin G. Schwacha and Kirby I. Bland and Irshad H. Chaudry},
  journal={Endocrinology},
  year={2001},
  volume={142 8},
  pages={3519-3529}
}
Immune responses are suppressed in males, but not in proestrous females, after trauma-hemorrhage. Testosterone and 17b-estradiol appear to be responsible for divergent immune effects. There is considerable evidence to suggest sex steroid hormone involvement in immune functions. As formation of active steroid depends on the activity of androgenand estrogen-synthesizing enzymes, expression and activity of 5areductase, aromatase, and 3band 17bhydroxysteroid dehydrogenases were determined in spleen… CONTINUE READING
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