Divergent Evolution of ( )8-Barrel Enzymes

@inproceedings{HennSax2001DivergentEO,
  title={Divergent Evolution of ( )8-Barrel Enzymes},
  author={Martina Henn-Sax and Birte H{\"o}cker and Matthias Wilmanns and Reinhard Sterner},
  year={2001}
}
lationship), superfamilies (probable common evolutionary origin) and folds (Murzin et al., 1995). Proteins are defined to have a common fold if they have the same major secondary structures in the same spatial arrangement and the same topological connections. SCOP currently distinguishes between several hundred different folds. The (βα)8(or TIM-)barrel is a frequently encountered fold, which comprises about 10% of all known protein structures (Gerlt, 2000). (βα)8-barrel enzymes catalyse a vast… CONTINUE READING
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Directed evolution

  • C. Jürgens, A. Strom, D. Wegener, S. Hettwer, M Wilmanns., R. Sterner
  • 2000
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