Divergent Evolution of ( )8-Barrel Enzymes

  title={Divergent Evolution of ( )8-Barrel Enzymes},
  author={Martina Henn-Sax and Birte H{\"o}cker and Matthias Wilmanns and Reinhard Sterner},
lationship), superfamilies (probable common evolutionary origin) and folds (Murzin et al., 1995). Proteins are defined to have a common fold if they have the same major secondary structures in the same spatial arrangement and the same topological connections. SCOP currently distinguishes between several hundred different folds. The (βα)8(or TIM-)barrel is a frequently encountered fold, which comprises about 10% of all known protein structures (Gerlt, 2000). (βα)8-barrel enzymes catalyse a vast… CONTINUE READING
13 Citations
32 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Directed evolution

  • C. Jürgens, A. Strom, D. Wegener, S. Hettwer, M Wilmanns., R. Sterner
  • 2000
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…