Divergence of immunologic and protective responses of different BCG strains in a murine model.

@article{Kozak2011DivergenceOI,
  title={Divergence of immunologic and protective responses of different BCG strains in a murine model.},
  author={Ray Kozak and Marcel A. Behr},
  journal={Vaccine},
  year={2011},
  volume={29 7},
  pages={1519-26}
}
The ongoing evolution of BCG after its introduction in 1921 resulted in strains that differ genetically and phenotypically. Based on a genomic deletion (Region of Difference 2 or RD2) that occurred between 1927 and 1931, BCG strains can be sub-classified by the presence or absence of RD2. The existence of other mutations that distinguish BCG strains precludes simple comparison of RD2-positive and RD2-negative BCG strains to determine the importance, if any, of RD2 for vaccine protection. In… CONTINUE READING

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