Divergence of binding sites, in vitro action, and secretory regulation of the somatomedin peptides, IGF-I and IGF-II.

@article{Daughaday1982DivergenceOB,
  title={Divergence of binding sites, in vitro action, and secretory regulation of the somatomedin peptides, IGF-I and IGF-II.},
  author={William H. Daughaday},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1982},
  volume={170 3},
  pages={
          257-63
        }
}
Three separate lines of research, initially perceived as unrelated, have converged to form the present field of the somatomedins and the insulin-like growth factors (see (1,2) for early reviews). Because these separate areas of research evolved their own terminology, there is a confusing array of names for the different factors under study. The first of these areas of research was based on the observation that a key target tissue of growth hormone in vivo responsible for the skeletal growth… CONTINUE READING

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