Divergence of Transcription Factor Binding Sites Across Related Yeast Species

@article{Borneman2007DivergenceOT,
  title={Divergence of Transcription Factor Binding Sites Across Related Yeast Species},
  author={A. Borneman and T. Gianoulis and Z. Zhang and H. Yu and J. Rozowsky and Michael R. Seringhaus and L. Wang and M. Gerstein and M. Snyder},
  journal={Science},
  year={2007},
  volume={317},
  pages={815 - 819}
}
Characterization of interspecies differences in gene regulation is crucial for understanding the molecular basis of both phenotypic diversity and evolution. By means of chromatin immunoprecipitation and DNA microarray analysis, the divergence in the binding sites of the pseudohyphal regulators Ste12 and Tec1 was determined in the yeasts Saccharomyces cerevisiae, S. mikatae, and S. bayanus under pseudohyphal conditions. We have shown that most of these sites have diverged across these species… Expand
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