Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

  title={Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure},
  author={Nina Balthasar and Louise Torp Dalgaard and Charlotte E. Lee and Jia Huan Yu and Hisayuki Funahashi and Todd O. Williams and Manuel Ferreira and Vinsee Tang and Robert A. McGovern and Christopher D. Kenny and Lauryn M. Christiansen and Elizabeth Edelstein and Brian J. Choi and Olivier Boss and Carl J. Aschkenasi and Chen-Yu Zhang and Kathleen G. Mountjoy and Toshiro Kishi and Joel K Elmquist and Bradford B. Lowell},
Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by decreasing food intake and increasing energy expenditure. MC4Rs are expressed in multiple CNS sites, any number of which could mediate these effects. To identify the functionally relevant sites of MC4R expression, we generated a loxP-modified, null Mc4r allele (loxTB Mc4r) that can be reactivated by Cre-recombinase. Mice homozygous for the loxTB Mc4r allele do not express MC4Rs and are markedly obese. Restoration of MC4R… CONTINUE READING
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europeptide Y Y1 receptor mRNA in rodent brain: distribution and olocalization with melanocortin-4 receptor

  • T. ishi, C. J. Aschkenasi, +6 authors J. K. Elmquist
  • J. Comp. Neurol
  • 2005

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