Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.

@article{Salazar2008DivalentMT,
  title={Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.},
  author={Julio Salazar and Natalia Mena and St{\'e}phane Hunot and Annick Prigent and D. Alvarez-Fischer and M Arredondo and Charles Duyckaerts and V{\'e}ronique Sazdovitch and Lin Zhao and Laura M. Garrick and Marco T. Nu{\~n}ez and Michael D. Garrick and Rita Raisman-Vozari and Etienne C. Hirsch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 47},
  pages={
          18578-83
        }
}
Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in the SN of PD patients may contribute to the generation of oxidative stress, protein aggregation, and neuronal death. The mechanisms involved in iron accumulation also remain unclear. Here, we describe an increase in the expression of an isoform of the divalent metal transporter… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 152 CITATIONS, ESTIMATED 53% COVERAGE

290 Citations

02040'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 290 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Gene expression profiling of MPP -treated MN9D cells: A mechanism of toxicity study

  • J Wang
  • Neurotoxicology
  • 2007
Highly Influential
7 Excerpts

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson’s disease

  • G Boka
  • Neurosci Lett
  • 1994
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…