Divalent cobalt as a label to study lymphocyte distribution using PET and SPECT.

@article{Korf1998DivalentCA,
  title={Divalent cobalt as a label to study lymphocyte distribution using PET and SPECT.},
  author={Jakob Korf and L Veenma-van der Duin and R Brinkman-Medema and Anita E. Niemarkt and Lou F. M. H. de Leij},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1998},
  volume={39 5},
  pages={836-41}
}
UNLABELLED PET and SPECT allow the study of the distribution of lymphocytes in living humans, provided that these cells are adequately prelabeled ex vivo. Such a labeling technique should not only be nontoxic to lymphocytes but it also should take into consideration that their kinetics are such that radioactivity must be followed for at least 24 hr. We describe the potential of divalent cobalt isotopes (55Co2+, half-life 17.5 hr for PET; 57Co2+, half-life 270 days for SPECT) for labeling… CONTINUE READING

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