Divalent cations modulate the activity of metabotropic glutamate receptors.

  title={Divalent cations modulate the activity of metabotropic glutamate receptors.},
  author={Anna Francesconi and Robert M. Duvoisin},
  journal={Journal of neuroscience research},
  volume={75 4},
Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, recent findings have demonstrated that mGluRs can respond to high extracellular Ca2+ (Ca2+(o)) whereas CaR activity is potentiated by L-amino acids. We show that both mGluR1 and mGluR2… CONTINUE READING
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