Divalent cations: do they stabilize the agonist (12S) form of the mu opioid receptor?

@article{Jauzac1984DivalentCD,
  title={Divalent cations: do they stabilize the agonist (12S) form of the mu opioid receptor?},
  author={Ph Jauzac and Bernard Franc{\'e}s and Alain Puget and J. C. Meunier},
  journal={Neuropeptides},
  year={1984},
  volume={5 1-3},
  pages={125-8}
}
In rabbit cerebellum membranes, millimolar concentrations of Mn++ ions while slightly reducing the Kd of 3H-etorphine counteract, to a large extent, sodium inhibition of equilibrium binding of the tritiated agonist to the mu opioid receptor. In digitonin extracts of membranes which have been incubated either with 3H-etorphine or with 3H-diprenorphine in the… CONTINUE READING