Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes.

@article{Ellison2000DivalentCT,
  title={Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes.},
  author={David H Ellison},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 4},
  pages={F616-25}
}
  • David H Ellison
  • Published 2000 in American journal of physiology. Renal physiology
Elucidation of the gene defects responsible for many disorders of renal fluid and electrolyte homeostasis has provided new insights into normal and abnormal physiology. Identifying the causes of Gitelman's and Bartter's syndromes has greatly enhanced our understanding of ion transport by thick ascending limb and distal convoluted tubule cells. Despite this information, several phenotypic features of these diseases remain confusing, even in the face of molecular insight. Paramount among these… CONTINUE READING

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