Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids.

@article{Stavinoha2004DiurnalVI,
  title={Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids.},
  author={Melissa A Stavinoha and Joseph W Rayspellicy and Mary L Hart-Sailors and Harry John Mersmann and Molly S. Bray and Martin Elliot Young},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={287 5},
  pages={E878-87}
}
Cardiac and skeletal muscle both respond to elevated fatty acid availability by increasing fatty acid oxidation, an effect mediated in large part by peroxisome proliferator-activated receptor-alpha (PPAR alpha). We hypothesized that cardiac and skeletal muscle alter their responsiveness to fatty acids over the course of the day, allowing optimal adaptation when availability of this substrate increases. In the current study, pyruvate dehydrogenase kinase 4 (pdk4) was utilized as a representative… CONTINUE READING

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Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

  • J Hoeks, MKC Hesselink, +4 authors P. Schrauwen
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